Table 1. Principal demographic and clinical characteristics of studied subjects.
Abbreviations: HET = heterozygous; HOM = homozygous; HC = healthy controls; SD = standard deviation; LEDD = Levodopa equivalent daily dose; UPDRS = Unified Parkinson's Disease Rating Scale; MOCA = Montreal Cognitive Assessment; H&Y = Hoehn and Yahr scale.
| HC (n = 22) | HET (n = 12) | HOM (n = 8) | |
|---|---|---|---|
| Age at scan (SD) | 47.0 (12.2) | 41.9 (14.8) | 51.4 (8.1) |
| Sex (M/F) | 10/12 | 5/7 | 6/2 |
| Educational level (SD) | 14.7 (3.2) | 12.3 (2.1) | 11.4 (2.3)* |
| MOCA | / | 23.8 (1.8) ° | 23.0 (2.6) ° |
| Diagnosis | / | 10 unaffected/ 2 possibly affected | Affected |
| Disease duration | / | / | 18.2 (8.5) |
| Pink/Parkin | / | 10/2 | 5/3 |
| LEDD | / | / | 590.9 (358.1) |
| UPDRS | / | 1.7 (3.7) | 23.2 (19.9)# |
| H&Y | / | / | 2.2 (0.9) |
* HC vs. HOM/HET p< 0.05
° pathological score
# HOM vs. HET p< 0.05.