Table 3. Kidney function and calciotropic and phosphaturic hormones before and at different time points after left ventricular assist device implantation, broken down by survival status.
| Parameter | t0 | t1 | t2 | t3 | t4 | P-value |
|---|---|---|---|---|---|---|
| Non-Survivors (n = 45) | n = 45 | n = 32 | n = 41 | n = 32 | n = 19 | |
| eGFR (ml/min/1.73m2) | 50 (35;70)* | 75 (41;107)** | 84 (54;104) | 71 (38;95) | 50 (34;80) | 0.013 |
| 25OHD (ng/ml) | 10.8 (8.2;17.6) | 11.0 (8.6;15.8) | 11.0 (8.0;13.7) | 10.3 (8.5;14.7) | 11.1 (9.2;14.6) | 0.988 |
| PTH (pg/ml) | 40 (32;95) | 76 (37;129) | 48 (22;73) | 39 (20;62) | 49 (21;65) | 0.058 |
| 1,25(OH)2D (pg/ml) | 7.7 (4.9;12.5) | 7.3 (4.9;11.4) | 7.5 (4.9;12.6) | 10.3 (6.1;20.1) | 10.6 (4.9;15.5) | 0.599 |
| FGF-23 (RU/ml) | 612 (267;2356) | 963 (381;2021) | 409 (251;1007)* | 435 (323;1217) | 500 (334;1513) | 0.173 |
| Survivors (n = 24) | n = 24 | n = 19 | n = 21 | n = 15 | n = 16 | |
| eGFR (ml/min/1.73m2) | 75 (50;96)+ | 107 (68;138)*,+ | 95 (74;115)* | 72 (58;111) | 62 (49;84) | 0.012 |
| 25OHD (ng/ml) | 13.1 (11.1;21.5) | 11.8 (7.7;18.5) | 10.8 (7.6;16.0) | 12.3 (7.1;13.5) | 11.3 (6.5;14.3) | 0.271 |
| PTH (pg/ml) | 49 (33;102) | 54 (34;76) | 46 (25;94) | 73 (28;91) | 64 (47;88) | 0.696 |
| 1,25(OH)2D (pg/ml) | 8.1 (4.9;20.0) | 9.6 (4.9;11.5) | 12.4 (4.9;18.1) | 12.8 (8.8;34.7) | 22.2 (7.6;28.0)*,++ | 0.016 |
| FGF-23 (RU/ml) | 1055 (340;3301) | 1204 (545;2297) | 425 (339;957) | 477 (249;795) | 539 (212;1096) | 0.062 |
Data are expressed as median and interquartile range. Abbreviations: eGFR, estimated glomerular filtration rate; 25OHD, 25-hydroxyvitamin D, PTH, parathyroid hormone; 1,25(OH)2D, 1,25-dihydroxyvitamin D; FGF-23, fibroblast growth factor-23; t0, before assist device implantation; t1,12 days post-intervention; t2, 30 days post-intervention; t3, 83 days post-intervention; t4, 300 days post-intervention *,** significant different vs. t0, *P<0.05;**P<0.01; +,++ significant different vs. non-survivors at the same time point, +P<0.05; ++P<0.01