Figure 4.

CRY variants show divergent sensitivity to MF exposure. A, Representative electrophysiological recordings from L3 aCC/RP2-expressing CRY variants: CRY^W342F and a C-terminal truncation (CRY^Δ14.6). Mutagenesis of W342 within the triad responsible for the RPM reveals that this residue is not essential for the MF response. Conversely, deletion of the CRY C-terminus dramatically affects the MF-dependent potentiation without compromising photoactivation by BL. B, Quantitative analysis of MF effect on the BL-induced V_m changes to cells expressing CRY variants. C, RMP measured before light stimulation. All values shown are means ± SEM and n is shown in each bar. **p < 0.01.