Table 3.

Biophysical properties of TTX-R and TTX-S Na⁺ currents in neurons from V1^Gi-DREAD mice (n = 15) and littermate controls (n = 10)

	Inactivation		Activation
	V1/2 (mV)	Slope	V1/2 (mV)	Slope
TTX-R
Control	−26.8 ± 1.4	3.8 ± 0.2	−9.2 ± 1.0	5.3 ± 0.2
V1Gi-DREADD	−24.9 ± 0.9	3.9 ± 0.2	−8.8 ± 1.2	5.6 ± 0.2
TTX-S
Control	−72.1 ± 2.6	5.2 ± 0.3	−22.2 ± 0.3	5.2 ± 0.6
V1Gi-DREADD	−55.8 ± 1.7**	5.9 ± 0.3	−19.6 ± 1.0*	5.9 ± 0.3

Conductance–voltage data were fitted with a Boltzmann equation to estimate the potential at which half-maximal conductance was activated (V_1/2) and sloped. Student's t test was used to assess differences in current properties.

* Indicates a significant difference between V1^Gi-DREADD and littermate controls where *p < 0.05,

**p < 0.01.