Table 2.
Comparisons of synaptic and membrane properties between wild-type and two zebrafish
| Properties | Wild-type | two | p-value |
|---|---|---|---|
| Spontaneous mEPC frequency (events/min) | 17.8 ± 8.4 (n = 11) | 18.5 ± 13.7 (n = 9) | 0.9 |
| Spontaneous mEPC amplitude (pA) | 1406 ± 166 (n = 11) | 85 ± 7 (n = 9) | **** |
| Spontaneous mEPC CV | 0.40 ± 0.09 (n = 11) | 0.33 ± 0.05 (n = 9) | 0.05 |
| Asynchronous mEPC amplitude (pA) | 1543 ± 351 (n = 17) | 108 ± 21 (n = 13) | **** |
| Asynchronous mEPC CV | 0.35 ± 0.12 (n = 17) | 0.35 ± 0.06 (n = 13) | 0.98 |
| EPC amplitude (nA) | 18.1 ± 4.6 (n = 17) | 2.9 ± 2.4 (n = 13) | **** |
| Quantal content | 12.0 ± 2.6 (n = 17) | 25.9 ± 16.9 (n = 13) | ** |
| N | 13.6 ± 3.2 (n = 17) | 42.3 ± 27.6 (n = 13) | *** |
| Pr | 0.9 ± 0.1 (n = 17) | 0.7 ± 0.2 (n = 13) | *** |
| Paired-pulse ratio; 20 Hz | 0.72 ± 0.15(n = 8) | 0.55 ± 0.14 (n = 10) | * |
| Paired-pulse ratio; 50 Hz | 0.78 ± 0.13 (n = 7) | 0.54 ± 0.14 (n = 9) | ** |
| Paired-pulse ratio; 100 Hz | 0.74 ± 0.05 (n = 11) | 0.52 ± 0.09 (n = 13) | **** |
| Steady-state depression level; 20 Hz | 0.33 ± 0.05(n = 8) | 0.22 ± 0.03 (n = 10) | **** |
| Steady-state depression level; 50 Hz | 0.29 ± 0.04 (n = 7) | 0.18 ± 0.03(n = 9) | **** |
| Steady-state depression level; 100 Hz | 0.28 ± 0.05 (n = 11) | 0.14 ± 0.02 (n = 13) | **** |
| RRP/site (vesicles); 20 Hz | 2.0 ± 0.3 (n = 8) | 1.4 ± 0.4 (n = 10) | ** |
| RRP/site (vesicles); 50 Hz | 2.2 ± 0.2 (n = 7) | 1.4 ± 0.3 (n = 9) | **** |
| RRP/site (vesicles); 100 Hz | 2.2 ± 0.3 (n = 11) | 1.5 ± 0.5 (n = 13) | *** |
| Reloading rate/site (vesicle/ms); 20 Hz | 0.007 ± 0.001 (n = 8) | 0.004 ± 0.001 (n = 10) | **** |
| Reloading rate/site (vesicle/ms); 50 Hz | 0.014 ± 0.003 (n = 7) | 0.007 ± 0.002 (n = 9) | **** |
| Reloading rate/site (vesicle/ms); 100 Hz | 0.027 ± 0.005 (n = 11) | 0.012 ± 0.004 (n = 13) | **** |
| Muscle input resistance (MΩ) | 397.4 ± 173.5 (n = 16) | 385.0 ± 232.4 (n = 20) | 0.86 |
| Muscle membrane capacitance (pF) | 70.4 ± 13.8 (n = 16) | 70.0 ± 15.7 (n = 20) | 0.95 |
| Muscle resting potential (mV) | −62.7 ± 2.0 (n = 9) | −64 ± 3.8 (n = 11) | 0.31 |
All data are presented as mean ± SD, with the number of cells indicated in parentheses.
****p < 0.0001,
***p < 0.001,
**p < 0.01,
*p < 0.05, 2-tailed t test. Part of the wild-type data were published previously (Wen et al., 2016) and are shown here for comparison with the two data.