Fig. 4.

Enrichment of highly correlated, co-occurring protein pairs. The PPI fold enrichment of co-occurring protein pairs with CC values in both HIC and SEC dimensions ≥0.85 (Experimental Procedures; supplemental Table S1)). PPI fold enrichments are shown for different sets of protein pairs. To the left are the three benchmark data sets, though in this case D. vulgaris pairs were not included in the reciprocal AP-MS PPIs. Next are our two AP-MS interactomes for D. vulgaris and E. coli; the set of negative pairs unlikely to interact and the set of all co occurring protein pairs; and finally the nine earlier Y2H and AP-MS interactomes. The set of all co occurring protein pairs by definition have a PPI fold enrichment of 1.