Table V. Human counterparts of No-enriched rat brain proteins whose mutations cause neurodegenerative diseases.

Protein	No/Nu	Function	Disease/neurological phenotype	OMIM#/(Reference)
EWSR1	1.9	RNA binding protein, RNA splicing, ribosomal biogenesis	Amyotrophic Lateral Sclerosis	(Couthouis et al. 2012)a
TARDBP	1.45	DNA/RNA binding protein, RNA splicing	Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia; Als10	612069
LMNB1	1.47	nuclear envelop protein	Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant (LMNB1 duplication); ADLD; cerebellar ataxia, cognitive decline, personality changes due to degeneration of the CNS white matter	169500

^a Couthouis, J. et al. (2012) Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum. Mol. Genet. 21, 2899–911.