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. Author manuscript; available in PMC: 2017 Jan 13.
Published in final edited form as: J Antibiot (Tokyo). 2016 Jul 13;69(10):731–740. doi: 10.1038/ja.2016.88

Figure 4.

Figure 4

Structure comparison between SgcJ and selected homologous in the NTF2-like superfamily. (a) Each structure shows a curved antiparallel β-sheet wall with a group of α-helices on one side of the wall to form the cone-like shapes. The putative general base and acid are shown as yellow and green sticks, respectively. The water molecule in the structure of mgSD is depicted by a red dot. Given in parentheses are PDB accession codes for each of the structures. (b) The proposed mechanisms for KSI, mgSD, SnoaL, and Tcm ARO/CYC, featuring the conserved general acid-base pairs to catalyze the initial steps of reactions.