Table 2b.

Continuous, longitudinal association between age and grip strength stratified by HIV status. October 1, 2007 – September 30, 2014 (N=1,552)

Dependent variable: Grip strength (kg)	HIV+			HIV−
	N = 716			N = 836
Independent variables:	Coefficient	SE	p-value	Coefficient	SE	p-value
Age (centered at 50 years)	−0.525	.060	< 0.001	−0.394	.044	< 0.001
Age squared	−0.002	.003	0.49	−0.006	.002	< 0.001
Body mass index (kg/m2)	0.233	.046	< 0.001	0.047	.035	0.178
Non-White Racea	−1.233	.639	0.06	−1.466	.689	0.03
College educationb	2.293	.600	< 0.001	1.243	.569	0.03
Kidney diseasec	−0.189	.183	0.30	−0.502	.164	< 0.01
Peripheral Neuropathyd	−0.316	.194	0.10	−0.132	.167	0.43
Hepatitis Ce	−1.597	.681	0.02	1.338	.852	0.12
History of AIDSf	−1.081	.657	0.10
Cumulative Viral Load ≤ 3.0g (log10 copy-years/mL)	Ref.
Cumulative Viral Load 3.1 – 4.0 (log10 copy-years/mL)	− 0.884	.427	0.04
Cumulative Viral Load ≥ 4.1(log10 copy-years/mL)	− 1.077	.399	0.01

Table 3 shows the final longitudinal model assessing the associations among age and grip strength decline, stratified by HIV serostatus. Smoking, history of drug and alcohol use, hypertension, arthritis, mental quality of life, and hepatitis B were not significant and were not included in the final model.

^aBlack (non-Hispanic), Black Hispanic, American Indian or Alaskan Native, Asian or Pacific Islander, other Hispanic, or other

^bCompleted college degree or more

^cEstimated Glomerular Filtration Rate < 60 or Urine Protein to Creatinine Ratio ≥ 200

^dCurrent or past report of pain, burning, numbness, or pins and needles sensation in the feet or legs, or measured inability to detect vibratory sensation in either foot

^eDetectable hepatitis C RNA in serum

^fFirst AIDS diagnosis at or before current visit

^gA measure of cumulative HIV burden that estimates the area under each participant’s longitudinal viral load curve