Table 1.
Subject demographics and clinical information
| Subject ID | Age (years) | Gender | Weight (kg) | Height (cm) | FEV1% predicted | Predicted TLC (L) | Number of 129Xe doses | CF genotype | CF pathogensb |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers (n=17) | |||||||||
| HV-1a | 11 | F | 35.1 | 148.5 | 100% | 3.59 | 2 | - | - |
| HV-2a | 14 | M | 49.1 | 164.6 | NA | 4.94 | 2 | - | - |
| HV-3a | 10 | M | 100.7 | 148.7 | 127% | 3.81 | 2 | - | - |
| HV-4a | 10 | M | 39.6 | 138.8 | 91% | 3.19 | 2 | - | - |
| HV-5a | 7 | F | 27.4 | 122.5 | 106% | 2.19 | 2 | - | - |
| HV-6 | 7 | F | 33 | 128.4 | 115% | 2.47 | 2 | - | - |
| HV-7 | 7 | M | 24.9 | 123.2 | 99% | 2.35 | 2 | - | - |
| HV-8 | 14 | M | 40.6 | 150 | 108% | 3.89 | 2 | - | - |
| HV-9 | 14 | M | 64.8 | 176.8 | 106% | 5.94 | 2 | - | - |
| HV-10 | 15 | F | 51.5 | 158.5 | 110% | 4.25 | 2 | - | - |
| HV-11 | 12 | M | 34.8 | 140.9 | 103% | 3.32 | 2 | - | - |
| HV-12 | 13 | M | 57.2 | 171.2 | 109% | 5.47 | 2 | - | - |
| HV-13 | 13 | M | 45.8 | 160 | 89% | 4.60 | 2 | - | - |
| HV-14 | 12 | M | 56.6 | 159.9 | 92% | 4.59 | 2 | - | - |
| HV-15 | 8 | M | 35.2 | 136 | 91% | 3.03 | 2 | - | - |
| HV-16 | 6 | F | 20.8 | 115.5 | 95% | 1.88 | 3 | - | - |
| HV-17 | 16 | F | 49.6 | 169.2 | 110% | 5.03 | 3 | - | - |
| Children with cystic fibrosis (n=11) | |||||||||
| CF-1 | 14 | M | 54.4 | 167 | 97% | 5.13 | 2 | F508Δ / F508Δ | Sa, A, Ca |
| CF-2 | 12 | F | 43.6 | 162 | 77% | 4.50 | 2 | F508Δ / F508Δ | A, Sp |
| CF-3 | 13 | F | 48.9 | 161 | 96% | 4.43 | 2 | G551D / F508Δ | - |
| CF-4 | 14 | F | 51.2 | 156 | 106% | 4.08 | 2 | L206W / F508Δ | Sa, Hi |
| CF-5 | 16 | M | 65.5 | 179 | 120% | 6.13 | 2 | F508Δ / F508Δ | Sm |
| CF-6 | 8 | M | 27.8 | 126 | 118% | 2.49 | 3 | F508Δ / F508Δ | Hi |
| CF-7 | 11 | M | 34.5 | 141.8 | 102% | 3.37 | 3 | R1066H / F508Δ | - |
| CF-8 | 13 | F | 46.5 | 157 | 114% | 4.15 | 2 | G178R / F508Δ | Hi |
| CF-9 | 15 | F | 43.7 | 159 | 72% | 4.29 | 2 | F508Δ / F508Δ | Sa, Pa |
| CF-10 | 11 | F | 40.1 | 152 | 89% | 3.82 | 2 | F508Δ / F508Δ | Sa |
| CF-11 | 11 | F | 34.3 | 147 | 86% | 3.50 | 2 | F508Δ / F508Δ | Pa |
a
Subject was imaged with half dose of xenon gas (1/12th predicted TLC)
b
Pathogens grown in respiratory cultures within 1 year prior to study
A Achromobacter, Ca Candida albicans, CF cystic fibrosis, F female, FEV1 forced expiratory volume in 1 second, Hi Haemophilus influenzae, HV healthy volunteers, ID identification, M male, NA not obtained for this child, Pa Pseudomonas aeruginosa, Sa Staphylococcus aureus, Sm Stenotrophomonas maltophilia, Sp Scedosporium prolificans, TLC total lung capacity