Table 3.

Summary of mean ± standard deviation SpO₂ changes during HP ¹²⁹Xe imaging for children receiving full doses of xenon gas

	All children (n=23)	Healthy controls (n=12; HV-6 through HV-17)	Children with CF (n=11)
Calibration dose
Baseline SpO2 (%)	98.0 ± 1.1	98.4 ± 1.0	97.6 ± 1.2
Nadir SpO2 (%)	95.1 ± 2.8	95.4 ± 2.4	94.8 ± 3.2
Mean difference from baseline SpO2 (%) [95% CI]	−2.9 [−4.2, −1.7]	−3.0 −4.6, −1.4]	−2.8 [−5.0, −0.6]
P-value (baseline vs. nadir)a	≤0.001	≤0.01	0.017
2-minute SpO2 (%)	97.5 ± 1.5	97.8 ± 1.8	97.3 ± 1.1
Mean difference from baseline SpO2 (%) [95% CI]	−0.5 [−1.1, 0.0]	−0.7 [−1.8, 0.4]	−0.4 [−0.82, 0.1]
P-value (baseline vs. 2-minute)a	0.069	0.21	0.10
Imaging dose
Baseline SpO2 (%)	97.9 ± 1.4	98.5 ± 1.2	97.3 ± 1.6
Nadir SpO2 (%)	92.0 ± 7.5	93.9 ± 4.0	89.9 ± 9.8
Mean difference from baseline SpO2 (%) [95% CI]	−6.0 [−8.8, −3.1]	−4.6 [−2.3, −7.0]	−7.4 [−13.1, −1.7]
P-value (baseline vs. nadir)a	≤0.001	≤0.001	0.015
2-minute SpO2 (%)	97.4 ± 1.7	97.5 ± 1.7	97.3 ± 1.8
Mean difference from baseline SpO2 (%) [95% CI]	−0.5 [−1.2, 0.1]	−1.0 [−0.2, −1.8]	0.0 [−1.0, 1.0]
P-value (baseline vs. 2-minute)a	0.11	0.024	1.0

^aP-value ≤ 0.05 is significant

CF cystic fibrosis, CI confidence interval, HV healthy volunteer, SpO₂ blood oxygenation