Table 3.
Partial Spearman Correlations adjusted for Age, Sex, Race, BMI, Current Smoking, Baseline CD4 and RNA (log-scale) level: HDLox, LDLox and Cellular Markers of immune Activation Measured Concurrently or Current Change from Baseline over Time.
| Week | 0 | 96 | Δ 96-0 | 0 | 96 | Δ 96-0 |
|---|---|---|---|---|---|---|
| Proinflammatory MNCs and Cellular markers of M/M activation | ||||||
| Parameter | % CD14dimCD16hi MNCs1 | % CD163+ MNCs2 | ||||
| nHDLox | −0.13 | −0.03 | −0.23** | 0.03 | 0.00 | −0.09 |
| LDLox | 0.00 | 0.00 | 0.01 | −0.02 | 0.01 | −0.08 |
| LDLox/LDL | −0.12 | 0.04 | −0.24** | −0.10 | 0.02 | −0.02 |
| Cellular markers of T cell activation | ||||||
| % CD38+DR+ CD8+ cells | # CD38 per CD8+ T cell3 | |||||
| nHDLox | 0.11 | 0.07 | 0.11 | 0.22** | 0.11 | 0.27** |
| LDLox | 0.08 | 0.05 | 0.09 | 0.06 | 0.05 | −0.09 |
| LDLox/LDL | 0.11 | 0.12 | 0.05 | 0.15* | 0.01 | 0.23** |
Nominal p-values presented. P>0.05 unless noted as statistically significant:
*
<0.05,
**
<0.01.
Significant (p<0.05) correlations are shown in italics and discrepant correlations between LDLox and LDLox/LDL are shown in bold. P values with false discovery rate (FDR) < 0.05 are underlined.
Similar results were observed for CD4+ and CD8+ T cells and:
1
CD14+CD16+MNCs;
2
MFI CD163 of CD163+ MNCs
3
% CD38+ CD8+ T cells (not shown)