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Inhibition of NOS with 100μm LNAME partially restores MetSyn contractility. A) Representative traces from both control and MetSyn MLVs at pressure 3cmH2O in APSS and in the presence of LNAME. The effect of LNAME on contraction frequency (B), normalized contraction frequency (C), and fractional pump flow (D) in control and MetSyn MLVs. Data are presented as Mean ± SEM n=4. 2-way ANOVA and Fisher post-hoc. * denotes p<0.05 LNAME as compared to the respective values in APSS.
