(A-B) Coronary arteries from B6.rag−/− recipients that received DSA
(α-H2k IgG2a). Notably, severely occluded vessels were
observed in close proximity to those that appeared completely normal and without
neointimal thickening (A), which illustrates the heterogeneous nature of lesion
formation. This is in comparison to (C), a widely patent coronary artery from a
B6.rag−/− recipient that received no treatment. (D) A widely
patent coronary artery from a B6.rag−/−γc−/−
recipient that received no treatment in comparison to (E), a severely stenotic
coronary artery from a B6.rag−/−γc−/−
recipient that received DSA in addition to adoptively transferred (1.5 ×
106) B6 wild-type NK cells. A-E, elastin stain, scale bar in 1A
equivalent in all other images (10x magnification). DSA, donor-specific
antibody.