Table 2.
Hazard ratio (95% CI) of cardiovascular mortality associated with FABP4, RBP4, and HMW adiponectin levels
| Tertiles levels
|
||||
|---|---|---|---|---|
| 1 | 2 | 3 | P for trend | |
| FABP4 | ||||
| Case/person years | 54/4681 | 67/4451 | 99/3971 | |
| Model 1* | 1.0 | 1.20 (0.84, 1.72) | 2.13 (1.53, 2.97) | <0.0001 |
| Model 2† | 1.0 | 1.16 (0.80, 1.68) | 1.80 (1.27, 2.57) | 0.0004 |
| Model 3‡ | 1.0 | 1.13 (0.77, 1.65) | 1.78 (1.22, 2.59) | 0.001 |
| RBP4 | ||||
| Case/person years | 72/4349 | 72/4441 | 76/4312 | |
| Model 1* | 1.0 | 0.93 (0.67, 1.29) | 0.95 (0.69, 1.31) | 0.76 |
| Model 2† | 1.0 | 1.00 (0.71, 1.40) | 0.87 (0.62, 1.23) | 0.43 |
| Model 3‡ | 1.0 | 0.92 (0.65, 1.30) | 0.73 (0.50, 1.07) | 0.09 |
| HMW adiponectin | ||||
| Case/person years | 57/4567 | 78/4456 | 85/4080 | |
| Model 1* | 1.0 | 1.27 (0.90, 1.79) | 1.45 (1.03, 2.03) | 0.04 |
| Model 2† | 1.0 | 1.30 (0.91, 1.86) | 1.76 (1.23, 2.51) | 0.002 |
| Model 3‡ | 1.0 | 1.40 (0.97, 2.01) | 2.07 (1.42, 3.06) | 0.0002 |
Model 1 was adjusted for age at blood draw.
Based on Model 1, Model 2 was further adjusted for date of blood draw (yr), body mass index at age 21 (kg/m2), physical activity (in quintiles), smoking status (never smoked, <10 pack-years, 10–24 pack-years, 25–44 pack-years, 45–64 pack-years, 65+ pack-years, missing), alcohol consumption (non-drinker, <5.0 g/day, 5.0–9.9 g/day, 10.0–14.9 g/day, 15.0–29.9 g/day, ≥30.0 g/day, missing), diabetes duration (yr), family history of myocardial infarction, aHEI score (in tertiles), use of aspirin or cholesterol-lowering medication (yes, no), baseline history of hypertension, high cholesterol, angina, CABG, myocardial infarction, and stroke (yes, no).
Based on Model 2, Model 3 was further adjusted for eGFR, triacylglycerol levels (mg/dL), high-density lipoprotein cholesterol (mg/dL), low-density lipoprotein cholesterol (mg/dL), and hsCRP.