Table 4. Effect of Hemin and Placebo Infusions on Laboratory Tests.
| Group | Baseline | Day 4 | Day 7 | Day 56 | |
|---|---|---|---|---|---|
| Hemoglobin (g/dL) | Placebo | 12.4 ± 0.5 | 11.5 ± 0.5 | 11.2 ± 0.4 | 11.2 ± 0.3 |
| Hemin | 12.1 ± 0.4 | 11.5 ± 0.5 | 11.6 ± 0.6 a | 11.3 ± 0.6 | |
| Erythrocyte count (×1012/L) | Placebo | 4.4 ± 0.1 | 4.1 ± 0.1 | 4.0 ± 0.1 | 4.0 ± 0.1 |
| Hemin | 4.1 ± 0.1 | 4.0 ± 0.1 | 4.0 ± 0.2 a | 4.0 ± 0.2 | |
| Leukocyte count (×109/L) | Placebo | 6.0 ± 0.5 | 6.2 ± 0.6 | 6.8 ± 1.2 | 6.5 ± 0.8 |
| Hemin | 7.0 ± 0.6 | 7.0 ± 0.5 | 7.2 ± 0.6 | 7.3 ± 0.5 | |
| Platelet count (×109/L) | Placebo | 266 ± 26 | 246 ± 21 | 248 ± 26 | 251 ± 41 |
| Hemin | 248 ± 18 | 194 ± 14 b | 201 ± 15 | 212 ± 12 | |
| Prothrombin time INR | Placebo | 0.9 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 |
| Hemin | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| APTT (seconds) | Placebo | 32 ± 0.9 | 31 ± 1.5 | 31 ± 1.4 | 32 ± 1.3 |
| Hemin | 32 ± 1.8 | 33 ± 1.0 | 30 ± 1.3 | 30 ± 1.2 | |
| Serum creatinine (mg/dL) | Placebo | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 |
| Hemin | 1.0 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | |
| Serum potassium (mmol/L) | Placebo | 4.3 ± 0.2 | 4.2 ± 0.1 | 4.3 ± 0.3 | 4.4 ± 0.1 |
| Hemin | 4.1 ± 0.1 | 4.4 ± 0.2 | 4.2 ± 0.1 | 4.0 ± 0.1 | |
| Total bilirubin (mg/dL) | Placebo | 0.4 ± 0.2 | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.4 ± 0.2 |
| Hemin | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.5 ± 0.1 | 0.5 ± 0.1 |
Abbreviations: APTT, Activated Partial Thromboplastin time; INR, International Normalized Ratio
a
P<.05,
b
P=.01,