Table 2.
Combination indices1 (CI) following dacarbazine and ABT-888 treatment in H727
| 5µM ABT-888 |
10µM ABT-888 |
|
|---|---|---|
| Dacarbazine(µM) | CI | |
| 10 | 2.49 | 2.59 |
| 25 | 1.32 | 3.48 |
| 50 | 0.96 | 1.41 |
| 100 | 1.12 | 1.19 |
| 200 | 1.22 | 1.08 |
| 300 | 1.25 | 1.05 |
| 400 | 1.19 | 0.96 |
| 500 | 1.25 | 0.88 |
| 750 | 0.61 | 0.78 |
| 1000 | 0.54 | 0.40 |
Calculated based on the Chou-Talalay method (>1:antagonism, =1:additivity, <1:synergy)