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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Exp Hematol. 2016 Jul 26;44(11):1013–1019. doi: 10.1016/j.exphem.2016.07.011

Figure 1. The structure of the iC9 suicide gene.

Figure 1

(A) The transgene consists of an inducible caspase 9 (iC9), and a selectable marker, truncated CD19 (ΔCD19), linked by a 2A-like sequence, which encodes a cleavable peptide. iC9 consists of a drug-binding domain (FKBP12-F36V) connected via a short linker (SGGGS) to human caspase 9. (B) Conditional Caspase 9 dimerization is induced in the presence of CID (AP1903), cleaving caspase 3 and leading to cell apoptosis.