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The effect of impaired kisspeptin signalling on metabolic receptor expression in 8 week (wk) gonad intact and gonadectomised (GNX) mice. Leptin receptor (Lepr) (A, E) ghrelin receptor (Ghsr) (B, F), melanocortin 3 receptor (Mc3r) (C, G) and melanocortin 4 receptor (Mc4r) (D, H) hypothalamic gene expression in males and females (WT – shown as white bars, Kiss1r KO – black bars). Values are the mean ± SEM. n=3–9 per group (n=3 in the intact female KO group only).
