Figure 3.
Influence of a low affinity endogenous agonist for TGR5 receptor, ursodeoxycholic acid (UDCA) on short-circuit current (Isc, in % baseline) (A) and transepithelial electrical resistance (TEER, in % baseline) (B) in seromuscularly-stripped preparations of rat distal colon mounted in Ussing chambers. UDCA administered on the serosal side at 60 μM reduced significantly the Isc at 35 min (A), but had no effect on TEER (4D). Data are means ± SEM, n as indicated in parenthesis. *p<0.05 (60 μM) and #p<0.05 (100 μM) vs DMSO group, two-way ANOVA followed by Bonferroni's multiple comparison post hoc test.