Fig. 8.

In situ identification of the status of zinc and ZIP1 in tissue sections of normal and malignant prostate. A. Shows zinc staining identifying high zinc (yellow stain) in the normal acinar epithelium versus low zinc (red stain) in malignancy. B. Shows prominent plasma membrane localized ZIP1 in the normal epithelium; and absence of ZIP1 in malignancy. C. Shows high gene expression (green) in the normal acinar epithelium; and the absence of gene expression (red) in malignancy. (Taken from Ref. [30].