Table 3.
Prevalence of Preoperative Brain Injury by Cardiac Diagnosis and Postnatal vs Prenatal Diagnosis of Critical Congenital Heart Disease
| Preoperative Brain Injury and Cardiac Diagnosis | No. With Injury/Total No. With Cardiac Diagnosis (%) | P Valuea | |
|---|---|---|---|
| Postnatal Diagnosis | Prenatal Diagnosis | ||
| Any injuryb | |||
| All patients | 41/86 (48) | 16/67 (24) | .003 |
| TGA | 31/68 (46) | 6/28 (21) | .03 |
| SVP | 10/18 (56) | 10/39 (26) | .03 |
| SVP with aortic arch obstruction | 9/17 (53) | 7/31 (23) | .02 |
| White matter injury | |||
| TGA | 17/68 (25) | 3/28 (11) | .09 |
| SVP | 8/18 (44) | 8/39 (21) | .06 |
| Stroke | |||
| TGA | 20/68 (29) | 4/28 (14) | .09 |
| SVP | 2/18 (11) | 5/39 (13) | .61 |
| Hypoxic-ischemic injuryc | |||
| TGA | 1/68 (1) | 0 | .71 |
| SVP | 1/18 (6) | 0 | .32 |
Abbreviations: SVP, single ventricle physiology; TGA, transposition of the great arteries.
a
Pearson χ2 test or Fisher exact test.
b
Any injury is defined as white matter injury and/or stroke.
c
Refers to watershed pattern of global hypoxic-ischemic injury.