Fig. 11.

Effects of ginkgolides and bilobalide on the expression of Bcl-2,BAx,Bak, RIP3, Caspase 3, and PARP-1 levels in BV2 microglia cells after OGD/R. After exposure to OGD for 4 h, BV2 cells were reoxygenated for either 6 h or 6 h followed by treatment with 50 μg/ml GAPIs, GA, GB, GK, and BB respectively. Representative graph (a) and quantitative data on the ratio of Bax/Bcl-2 (b), C-Caspase-3/Caspase-3 (d), C-PARP-1/ PARP-1 (e), and expression of Bak (c) and RIP3 (f) in BV2 microglia cells. GAPDH was used as the loading control. Western blot images are representative of three independent experiments. Each data point is a mean ± SD (n = 3). ^△ P < 0.01, ^△△ P < 0.05 as compared with control group; * P < 0.05, ** P < 0.01, as compared with model group