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. 2016 Sep 20;5(10):2678–2687. doi: 10.1002/cam4.788

Figure 4.

Figure 4

Prognostic significance of pNrf2 and Keap1 expression in 107 patients with HCC after curative resection. Cumulative overall survival (OS) time and disease‐free survival (DFS) time were calculated by Kaplan–Meier method and analyzed by log‐rank test. (A) Regarding the OS rate, significant difference was found between the group with high pNrf2 expression (n = 75) and the group with low pNrf2 expression (n = 32) (P = 0.0177). (B) Regarding the DFS rate, the group with high pNrf2 expression (n = 75) had a significantly poorer prognosis compared with the group with low pNrf2 expression (n = 32) (P = 0.0096). (C) Cumulative OS was not different between Keap1 reduced (n = 48) and preserved (n = 59) group (P = 0.0821). (D) Cumulative DFS was not different between Keap1 reduced (n = 48) and preserved (n = 59) group (P = 0.1422). (E) Cumulative OS was significant different between Keap1 reduced plus high pNrf2 expression (n = 40) and others (n = 67) group (P = 0.0252). (F) Cumulative DFS was significant different between Keap1 reduced plus high pNrf2 expression (n = 40) and preserved (n = 67) group (P = 0.0031). The data were presented as *P < 0.05, **P < 0.01.