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. 2016 Oct 5;78(5):1003–1011. doi: 10.1007/s00280-016-3156-x

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a QTcF and b baseline-adjusted QTcF (∆QTcF)^a interval-time profiles. Data are means + standard deviations. c Baseline-adjusted drug-placebo difference in QTcF interval (∆∆QTcF). Data are point estimates plus 95 % upper-bound time profiles. ^aFour patients had missing baseline or all post-baseline ECG interval measurements and were not included in ∆QTcF analyses for the regimen in which the information was missing. ECG electrocardiogram, QTcF corrected QT interval using Fridericia’s formula