Table 2.

Analysis of VAS Pain Intensity Score (intention-to-treat population)

Time point	Adjusteda change from baseline		Estimated treatment effect (95% confidence interval)	p value
	Methoxyflurane (N = 102)	Placebo (N = 101)
Overall	−29.0	−11.6	−17.4 (−22.3,−12.5)	<0.0001
5 min	−20.7	−8.0	−12.6 (−17.0, −8.3)
10 min	−27.4	−11.1	−16.3 (−21.4,−11.1)
15 min	−33.3	−12.3	−21.0 (−26.8,−15.3)
20 min	−34.8	−15.2	−19.7 (−26.0,−13.3)
Time by treatment interaction				0.0004

Pain scores recorded following the start of the planned emergency department procedure were excluded from the analysis. Pain scores taken after initiation of rescue medication were included in the analysis

VAS visual analog scale

^aLeast squares mean adjusted for baseline VAS pain score and time by treatment interaction