Table 3.
Analysis of secondary pain relief endpoints (intention-to-treat population)
| Endpoint | Statistic | Methoxyflurane (N = 102) | Placebo (N = 101) |
|---|---|---|---|
| Time to first pain relief | |||
| Kaplan–Meier estimatea (min) | Upper quartile (95% CI) | 10.0 (8.0, 17.0) | NC |
| Median (95% CI) | 5.0 (NC) | 20.0 (10.0, NC) | |
| Lower quartile (95% CI) | 2.0 (2.0, 4.0) | 5.0 (NC) | |
| Number (%) responses | 84 (82.4) | 53 (52.5) | |
| Number (%) censored | 18 (17.6) | 48 (47.5) | |
| Number of inhalations to first pain relief | No relief without rescue medication | 16 (15.7%) | 47 (46.5%) |
| 1 | 1 (1.0%) | 0 | |
| 2 | 6 (5.9%) | 2 (2.0%) | |
| 3 | 11 (10.8%) | 7 (6.9%) | |
| 4 | 19 (18.6%) | 3 (3.0%) | |
| 5 | 8 (7.8%) | 8 (7.9%) | |
| 6 | 9 (8.8%) | 7 (6.9%) | |
| 7 | 4 (3.9%) | 1 (1.0%) | |
| 8 | 10 (9.8%) | 4 (4.0%) | |
| 9 | 4 (3.9%) | 4 (4.0%) | |
| 10 | 9 (8.8%) | 9 (8.9%) | |
| >10 | 5 (4.9%) | 9 (8.9%) |
Times were censored at the soonest of; 2 h from start of treatment, investigator initiated rescue medication, start of treatment for the injury, early withdrawal
CI confidence interval, NC not calculable
aUnadjusted estimates