Table 1.

Main amino acid substitutions found in the hepatitis C virus NS3 protease

	Amino acid (frequency %)
	HCV genotype
	1a			1b			2a		2b		3a
Position	wt	Variants		wt	Variants		wt	Variants	wt	Variants	wt	Variants
36	V (98.08)	L (1.6)	M (0.32)	L (0.74)	I (0.25)	V (99.01)	L (100)	-	L (100)	-	L (100)	-
80	Q (54.37)	K (44.66)	R (0.97)	Q (93.37)	K (0.25)	L (6.39)	G (100)	-	G (100)	-	Q (100)	-
155	R (99.36)	K (0.64)	-	R (99.50)	P (0.50)	-	R (100)	-	R (100)	-	R (100)	-
156	A (100)	-	-	A (100)	-	-	A (100)	-	A (100)	-	A (100)	-
168	D (99.36)	E (0.32)	G (0.32)	D (98.77)	A (0.25)	E (0.98)	D (100)	-	D (100)	-	Q (100)	-

Amino acids in bold are associated with resistance. wt: Wild-type; HCV: Hepatitis C virus.