Table 2.

Main amino acid substitutions found in the hepatitis C virus NS5A protease

	Amino acid (frequency %)
	HCV genotype
	1a								1b								2a				2b				3a
Position	wt								wt								wt				wt				wt
28	M	94.38	I	0.37	T	0.75	V	4.49	L	97.17	M	2.27	V	0.52			F	100			L	100			M	96.46	I	3.57
30	Q	98.16	H	1.47	R	0.37			R	92.35	K	1.13	L/M	0.28	Q	5.95	K	94.74	R	5.26	K	100			A	96.46	L	3.57
31	L	98.88	M	1.12					L	96.03	M	3.40	I	0.57			M	84.21	L	15.79	M	76.92	L	23.08	L	100
93	Y	98.90	C	0.37	H	0.74			Y	95.75	H	4.25					Y	100			Y	100			Y	100

Amino acids in bold are associated with resistance. wt: Wild-type; HCV: Hepatitis C virus.