Table 4.
Changes in oxidative stress markers (SOD, CAT, GSH, TBARS, and NO) in heart, liver, and serum.
| Parameters | NC | HCF | HCF+FF | HCF+CAE1 | HCF+CAE2 | HCF+CAE1 | |
|---|---|---|---|---|---|---|---|
| Heart | SODa | 69.45 ± 3.4 | 38.16 ± 1.15+ | 65.39 ± 2.26 | 61.16 ± 0.01 | 64.99 ± 1.5 | 67.99 ± 1.5∗ |
| GSHb | 112 ± 5.6 | 60 ± 3.2++ | 80 ± 4 | 81.82 ± 2.7∗ | 87 ± 6.1∗∗ | 89 ± 6.21∗∗ | |
| TBARSc | 35.2 ± 1.6 | 52.32 ± 7.2+ | 41.1 ± 2.3 | 39.2 ± 3.2 | 38.61 ± 2.5 | 38.18 ± 2.1 | |
| NOd | 15.18 ± 1.34 | 27.14 ± 1.32 | 17.74 ± 1.31 | 21.32 ± 2.21 | 17.21 ± 1.0 | 13.21 ± 1.0 | |
| Liver | SODa | 86.35 ± 1.21 | 55.14 ± 1.11+ | 79.26 ± 1.03 | 70.31 ± 1.12 | 79.96 ± 2.2 | 81.16 ± 1.2∗∗ |
| GSHb | 350 ± 10 | 258 ± 6.5+ | 344 ± 4.5 | 318.17 ± 8.5 | 336 ± 6.7 | 356 ± 6.6∗ | |
| TBARSc | 76.4 ± 5.3 | 187.2 ± 7.1++ | 147.57 ± 8.1 | 116.2 ± 6.7 | 97.66 ± 7.230.6 | 82.4.7 ± 6.7∗∗ | |
| NOd | 21.47 ± 2.31 | 47 ± 3.26 | 23.64 ± 2.43 | 33.34 ± 2.7 | 5 ± 2.5 | 24.65 ± 0.5 | |
| Serum | SODa | 32.13 ± 1.13 | 19.49 ± 2++ | 22.43 ± 1.7 | 26.56 ± 5.23 | 28.32 ± 4.2 | 32.25 ± 2.1∗∗ |
| GSHe | 132 ± 5.3 | 201 ± 7.3 | 104 ± 4 | 114.89 ± 2.7 | 124.5 ± 5 | 130.2 ± 7.5 | |
| TBARSf | 29.2 ± 1.4 | 46.92 ± 3.6 | 37.37 ± 4.2 | 33.1 ± 2.27 | 27.62 ± 1.9 | 28.81 ± 2.1 | |
| NOg | 26.63 ± 1.51 | 56.56 ± 1.21 | 23.82 ± 1.51 | 39.51 ± 2.12 | 33.19 ± 1.1 | 25.23 ± 4.3 | |
CAE, Centella asiatica extract; NC, normal control; HCF, high cholesterol-fed; HCF+FF, high cholesterol-fed + fenofibrate; HCF+CAE1, high cholesterol-fed + Centella asiatica extract1 (0.25 g/kg b.w./day); HCF+CAE2, high cholesterol-fed + Centella asiatica extract2 (0.5 g/kg b.w./day); HCF+CAE3, high cholesterol-fed + Centella asiatica extract3 (1 g/kg b.w./day).
a% Inhibition, bμg/mg, cμM/mg, dμM/mg, eμg/mL, fμM/ mL, gμM/ mL. ∗p < 0.05 vs. HCF group, ∗∗p < 0.01 vs. HCF group, +p < 0.05 vs. NC group, ++p < 0.01 vs. NC group. n = 6, mean ± SEM.