Figure 4.

(a) Tumour blood flow (TBF) in patients with squamous cell carcinoma (SCC), aggressive inverted papilloma (IP) or non-aggressive IP. (b) Receiver operating characteristic (ROC) curve for the determination of diagnostic accuracy between SCC and non-aggressive IP. Among these three groups, significant differences in TBF values were observed between SCC (141.2 ± 33.1 ml 100 g⁻¹ min⁻¹) and non-aggressive IP (58.8 ± 19.9 ml 100 g⁻¹ min⁻¹) [(a): *, p < 0.01] and between the aggressive IP (109.4 ± 16.7 ml 100 g⁻¹ min⁻¹) and non-aggressive IP cases [(a): *2, p < 0.01]. No significant difference was observed between SCC and aggressive IP. In the ROC curve analysis (b), the AUC, sensitivity, specificity and accuracy for the differentiation of SCC and IP were 0.97, 0.91 (30/33), 1.0 (5/5) and 0.92 (35/38) with the threshold of 85–109 ml 100 g⁻¹ min⁻¹ [(a); *3]. Lines of thresholds for the sensitivity of 1.0 [(a): *4, 52–64 ml 100 g⁻¹ min⁻¹] and specificity of 1.0 [(a): *5, 85–109 ml 100 g⁻¹ min⁻¹] are shown.