Table 2. Liver and Blood Stage Potencies for Selected Compounds.
OSM-S- | P. berghei IC50 (nM) | cytotoxicity (HepG2, IC50, nM) | blood stage potency (3D7, nM) |
---|---|---|---|
5a,b | 24000, 14000 | 9800, 18000 | 502c |
38a,b | 19, 13 | >50000 | 79d |
111e | 350 | 4400 | 147d |
OSM-S- | P. berghei IC50 (nM) | cytotoxicity (HepG2, IC50, nM) | blood stage potency (3D7, nM) |
---|---|---|---|
5a,b | 24000, 14000 | 9800, 18000 | 502c |
38a,b | 19, 13 | >50000 | 79d |
111e | 350 | 4400 | 147d |