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. Author manuscript; available in PMC: 2017 May 11.
Published in final edited form as: J Am Chem Soc. 2016 Apr 28;138(18):5833–5836. doi: 10.1021/jacs.6b03373

Table 1.

IC50 Values of Promysalin Diastereomers and Active Compounds in μM (Compounds with IC50 > 250 μM Are Not Shown)a

graphic file with name nihms821861u1.jpg

PA01 PA14
1 (2R,8R) 4.1 0.067
1b (2R,8S) 46 6.6
1c (2S,8S) 90 22
1d (2S,8R) 33 4.3
6 111 28
9 7.7 0.019
10 32 12
11 57 6.7
18 5.8 0.035
19 38 11
21 8.3 0.067
a

Values are averages of three independent experiments (see SI for graphs and experimental details). A color-coded SAR is provided depicting the fold decrease in activity (right).