Figure 4. IFIH1 missense SNP genotypes correlate with Candida-induced cytokine levels.
PBMCs from healthy volunteers with different genotypes for (A) rs1990760 (candidemia risk allele T) and (B) rs3747517 (candidemia risk allele C) were stimulated in vitro with either C. albicans yeast or hyphae. Cytokine levels (scatterplots with mean indicated) were measured after 24 hours (IL-10) or 7 days (IL-17 and IFN-γ) by enzyme linked immunosorbent assay (ELISA). P values were calculated using the Mann-Whitney U test comparing cytokine levels of the two homozygous genotypes.