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. 2016 Sep 26;13:279. doi: 10.1186/s12974-016-0717-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Frequency and titers of MOG-IgG in 614 serum samples from 522 subjects as detected using a live-cell CBA. MOG-IgG was detected in 95/386 (24.6 %) samples in group I but was almost completely absent among 228 control samples (groups II–IV), including 89 samples from AQP4-IgG-positive patients, 85 samples from patients with MS according to the McDonald criteria (group III), and 54 samples from healthy controls and OND patients (group IV). While all low-titer samples (1:160–1:320) in group I were positive also in the fixed-cell CBA, the only positive control sample (from group IV) was negative in the fixed-cell CBA, suggesting a false-positive test result. The horizontal dashed line indicates the assay-specific cut-off (> = 1:160)