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Body weight changes and food consumption of copper nanoparticles (Cu NPs)- and copper microparticles (Cu MPs)-treated rats following 4 weeks-repeated oral dose. Repeated oral dose toxicity of Cu NPs and Cu MPs was assessed by determining (a, c) Body weight changes and (b, d) food consumption of Cu NPs- and Cu MPs-treated rats. Values are presented as mean ± SD (n = 10). *, ** P < 0.05, P < 0.01 versus vehicle control
