Table 4.
Top 10 GO Term and Broad MSigDB Canonical Pathway enrichments for 2 most correlated modules in PPvPT
| Module | GO Term | pGO | Broad MSigDB Canonical Pathway | pBroad |
|---|---|---|---|---|
| Sienna3 | regulation of leukocyte mediated cytotoxicity | 1.40E-05 | Genes involved in Lipid digestion, mobilization, and transport | 1.70E-05 |
| regulation of cell killing | 1.90E-05 | Antigen processing and presentation | 0.0002 | |
| leukocyte activation | 0.0001 | Genes involved in Neuronal System | 0.0004 | |
| T cell activation | 0.0001 | Genes involved in Lipoprotein metabolism | 0.0004 | |
| monosaccharide metabolic process | 0.0001 | Genes involved in Glucose metabolism | 0.0004 | |
| positive regulation of immune response | 0.0002 | Visual signal transduction: Cones | 0.0005 | |
| cytokine production | 0.0003 | Signaling events mediated by HDAC Class II | 0.0008 | |
| cell surface | 0.0005 | ABC transporters | 0.0011 | |
| MHC protein binding | 0.0005 | Downstream signaling in CD8+ T cells | 0.0015 | |
| microtubule organizing center | 0.0006 | Genes involved in Transmission across Chemical Synapses | 0.0015 | |
| Lightyellow | protein complex disassembly | 1.00E-10 | Ribosome, cytoplasmic | 2.10E-11 |
| protein targeting to ER | 1.10E-10 | Ribosome | 3.50E-11 | |
| establishment of protein localization to endoplasmic reticulum | 1.10E-10 | Genes involved in 3' -UTR-mediated translational regulation | 6.90E-11 | |
| viral infectious cycle | 2.20E-10 | Genes involved in Translation | 3.70E-10 | |
| macromolecular complex disassembly | 3.10E-10 | Genes involved in Peptide chain elongation | 7.30E-10 | |
| ribosomal subunit | 4.50E-10 | Genes involved in Influenza Viral RNA Transcription and Replication | 1.40E-09 | |
| cytosolic part | 3.50E-09 | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex | 1.70E-09 | |
| establishment of protein localization to organelle | 5.70E-09 | Genes involved in SRP-dependent cotranslational protein targeting to membrane | 1.90E-09 | |
| cellular component disassembly at cellular level | 1.20E-08 | Genes involved in Influenza Life Cycle | 4.30E-09 | |
| cellular component disassembly | 1.30E-08 | Genes involved in Metabolism of proteins | 5.30E-09 |