Table 1.
General characteristics and genotype distribution
| Variables | Total (n = 2239) | Female (n = 750) | Male (n = 1489) | P |
|---|---|---|---|---|
| Age, year | 46.70 ± 9.92 | 45.38 ± 9.40 | 47.37 ± 10.10 | <0.001 |
| Height, cm | 168.37 ± 7.67 | 161.80 ± 5.67 | 171.68 ± 6.28 | <0.001 |
| Weight, kg | 71.25 ± 12.50 | 61.60 ± 9.50 | 76.11 ± 10.91 | <0.001 |
| BMI, kg/m2 | 25.03 ± 3.52 | 23.52 ± 3.36 | 25.80 ± 3.34 | <0.001 |
| TGa, mmol/L | 1.00 (0.67–1.55) | 0.75 (0.53–1.15) | 1.18 (0.77–1.76) | <0.001 |
| TC, mmol/L | 4.98 ± 0.98 | 4.91 ± 0.98 | 5.01 ± 0.97 | 0.021 |
| HDL-C, mmol/L | 1.22 ± 0.33 | 1.32 ± 0.37 | 1.16 ± 0.29 | <0.001 |
| LDL-C, mmol/L | 2.77 ± 0.96 | 2.71 ± 0.94 | 2.79 ± 0.98 | 0.050 |
| SBP, mmHg | 130.26 ± 19.60 | 123.73 ± 18.52 | 133.54 ± 19.31 | <0.001 |
| DBP, mmHg | 82.45 ± 13.05 | 77.28 ± 11.01 | 85.05 ± 13.23 | <0.001 |
| FBG, mmol/L | 5.31 ± 1.30 | 5.07 ± 0.95 | 5.43 ± 1.20 | <0.001 |
| MTHFR C677T | ||||
| CC | 485 (21.67) | 165 (22.00) | 320 (21.49) | - |
| CT | 1071 (47.83) | 353 (47.07) | 718 (48.22) | - |
| TT | 683 (30.50) | 232 (30.93) | 451 (30.29) | 0.875 |
| C allele | 2041 (45.58) | 683 (45.53) | 1358 (45.60) | - |
| T allele | 2437 (54.42) | 817 (54.47) | 1620 (54.40) | 0.966 |
| MTRR A66G | ||||
| AA | 1285 (57.39) | 432 (57.60) | 853 (57.29) | - |
| AG | 801 (35.77) | 265 (35.33) | 536 (36.00) | - |
| GG | 153 (6.83) | 53 (7.07) | 100 (6.72) | 0.923 |
| A allele | 3371 (75.28) | 1129 (75.27) | 2242 (75.29) | - |
| G allele | 1107 (24.72) | 371 (24.73) | 736 (24.71) | 0.989 |
BMI body mass index, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, SBP systolic blood pressure, DBP diastolic blood pressure, FBG fasting blood glucose, MTHFR methylenetetrahydrofolate reductase, MTRR methionine synthase reductase
aThe value of TG was presented as median (interquartile range), and the difference in serum TG levels was determined by the Wilcoxon two-sample test