. 2016 Oct 28;15:185. doi: 10.1186/s12944-016-0354-9

Table 2.

Interaction of MTHFR C677T polymorphism with overweight/obesity on serum lipid levels

BMI	Genotype	n	TG (mmol/L)	Lg (TG)	TC (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)
Total
<24	CC	198	0.71 (0.53–1.07)	−0.10 ± 0.25	4.83 ± 1.07	1.32 ± 0.37	2.65 ± 0.97
	CT	438	0.76 (0.59–1.17)	−0.08 ± 0.24	4.86 ± 1.01	1.31 ± 0.34	2.68 ± 0.95
	TT	249	0.69 (0.49–1.02)	−0.12 ± 0.27	4.80 ± 0.95	1.34 ± 0.36	2.63 ± 0.92
≥ 24	CC	287	1.15 (0.78–1.81)	0.08 ± 0.26^{a, b, c}	5.02 ± 0.89	1.17 ± 0.32^{a, b, c}	2.79 ± 0.89
	CT	633	1.25 (0.86–1.85)	0.11 ± 0.27^{a, b, c}	5.12 ± 0.98^{a, b, c}	1.14 ± 0.28^{a, b, c}	2.92 ± 1.04^{a, b, c}
	TT	434	1.25 (0.86–1.77)	0.11 ± 0.27^{a, b, c}	5.02 ± 0.93	1.14 ± 0.28^{a, b, c}	2.74 ± 0.91
P* _interaction			-	0.268	0.668	0.268	0.296
Female
<24	CC	104	0.65 (0.50–0.89)	−0.16 ± 0.23	4.82 ± 1.03	1.39 ± 0.38	2.66 ± 0.93
	CT	224	0.71 (0.53–0.94)	−0.13 ± 0.24	4.85 ± 0.89	1.36 ± 0.36	2.68 ± 0.93
	TT	142	0.63 (0.44–0.90)	−0.16 ± 0.28	4.82 ± 1.01	1.40 ± 0.39	2.65 ± 0.98
≥ 24	CC	61	0.90 (0.60–1.15)	−0.07 ± 0.22	5.13 ± 0.98	1.28 ± 0.36	2.90 ± 0.87
	CT	129	0.99 (0.65–1.43)	0.00 ± 0.23^{a, b, c}	5.04 ± 0.98	1.23 ± 0.31^{a, b, c}	2.78 ± 0.90
	TT	90	1.09 (0.78–1.50)	0.05 ± 0.27^{a, b, c, d}	4.94 ± 1.10	1.17 ± 0.32^{a, b, c}	2.71 ± 1.01
P* _interaction			-	0.015	0.812	0.161	0.750
Male
<24	CC	94	0.81 (0.57–1.25)	−0.05 ± 0.25	4.83 ± 1.12	1.24 ± 0.35	2.65 ± 1.01
	CT	214	0.88 (0.65–1.32)	−0.03 ± 0.24	4.87 ± 1.12	1.26 ± 0.30	2.68 ± 0.97
	TT	107	0.79 (0.56–1.18)	−0.07 ± 0.25	4.77 ± 0.88	1.26 ± 0.31	2.60 ± 0.83
≥ 24	CC	226	1.24 (0.87–1.95)	0.12 ± 0.26^{a, b, c}	4.99 ± 0.87	1.14 ± 0.30^{a, b, c}	2.76 ± 0.89
	CT	504	1.32 (0.91–2.01)	0.14 ± 0.27^{a, b, c}	5.14 ± 0.98^{b, c}	1.12 ± 0.27^{a, b, c}	2.96 ± 1.07^{a, b, c}
	TT	344	1.28 (0.86–1.79)	0.12 ± 0.26^{a, b, c}	5.04 ± 0.89	1.13 ± 0.26^{a, b, c}	2.74 ± 0.88^e
P* _interaction			-	0.625	0.747	0.747	0.399

BMI body mass index, MTHFR methylenetetrahydrofolate reductase

*Adjusted for age

^a P < 0.05 in comparison with CC genotype of the BMI < 24 subgroup

^b P < 0.05 in comparison with CT genotype of the BMI < 24 subgroup

^c P < 0.05 in comparison with TT genotype of the BMI < 24 subgroup

^d P < 0.05 in comparison with CC genotype of the BMI ≥ 24 subgroup

^e P < 0.05 in comparison with CT genotype of the BMI ≥ 24 subgroup