Table 3.
Interaction of MTRR A66G polymorphism with overweight/obesity on serum lipid levels
| BMI | Genotype | n | TG (mmol/L) | Lg (TG) | TC (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) |
|---|---|---|---|---|---|---|---|
| Total | |||||||
| <24 | AA | 511 | 0.73 (0.54–1.10) | −0.10 ± 0.24 | 4.84 ± 1.01 | 1.31 ± 0.36 | 2.68 ± 0.96 |
| AG | 309 | 0.72 (0.53–1.07) | −0.10 ± 0.27 | 4.84 ± 1.02 | 1.35 ± 0.34 | 2.64 ± 0.93 | |
| GG | 65 | 0.77 (0.59–1.20) | −0.07 ± 0.25 | 4.82 ± 0.90 | 1.31 ± 0.36 | 2.62 ± 0.90 | |
| ≥ 24 | AA | 774 | 1.24 (0.86–1.87) | 0.11 ± 0.28a, b, c | 5.07 ± 0.93a, b | 1.14 ± 0.28a, b, c | 2.84 ± 0.96b |
| AG | 492 | 1.21 (0.84–1.69) | 0.09 ± 0.25a, b, c | 5.03 ± 0.98 | 1.14 ± 0.28a, b, c | 2.81 ± 0.99 | |
| GG | 88 | 1.21 (0.77–2.14) | 0.11 ± 0.27a, b, c | 5.22 ± 0.95 | 1.25 ± 0.33d, e | 2.95 ± 1.02 | |
| P* interaction | - | 0.438 | 0.688 | 0.050 | 0.608 | ||
| Female | |||||||
| <24 | AA | 277 | 0.69 (0.49–0.94) | −0.15 ± 0.24 | 4.80 ± 0.97 | 1.37 ± 0.38 | 2.65 ± 0.97 |
| AG | 158 | 0.66 (0.48–0.90) | −0.15 ± 0.27 | 4.88 ± 0.93 | 1.39 ± 0.36 | 2.70 ± 0.91 | |
| GG | 35 | 0.68 (0.52–0.89) | −0.14 ± 0.22 | 4.88 ± 1.00 | 1.39 ± 0.41 | 2.64 ± 0.90 | |
| ≥ 24 | AA | 155 | 0.96 (0.65–1.41) | −0.00 ± 0.25a, b | 5.01 ± 0.97 | 1.22 ± 0.31a, b | 2.72 ± 0.90 |
| AG | 107 | 1.00 (0.70–1.46) | 0.01 ± 0.25a, b | 5.01 ± 1.07 | 1.19 ± 0.31a, b, c | 2.84 ± 0.96 | |
| GG | 18 | 0.96 (0.57–1.19) | −0.02 ± 0.27 | 5.31 ± 1.12 | 1.46 ± 0.50f | 3.03 ± 1.01 | |
| P* interaction | - | 0.598 | 0.937 | 0.056 | 0.593 | ||
| Male | |||||||
| <24 | AA | 234 | 0.83 (0.63–1.24) | −0.05 ± 0.23 | 4.88 ± 1.06 | 1.23 ± 0.32 | 2.71 ± 0.95 |
| AG | 151 | 0.82 (0.57–1.25) | −0.06 ± 0.25 | 4.79 ± 1.11 | 1.29 ± 0.31 | 2.57 ± 0.95 | |
| GG | 30 | 1.02 (0.63–1.47) | 0.02 ± 0.26 | 4.75 ± 0.80 | 1.22 ± 0.28 | 2.60 ± 0.92 | |
| ≥ 24 | AA | 619 | 1.30 (0.90–1.97) | 0.14 ± 0.27a, b | 5.09 ± 0.92b | 1.12 ± 0.27a, b | 2.87 ± 0.97b |
| AG | 385 | 1.27 (0.87–1.78) | 0.11 ± 0.25a, b | 5.04 ± 0.95 | 1.13 ± 0.28a, b | 2.81 ± 1.00 | |
| GG | 70 | 1.32 (0.82–2.20) | 0.14 ± 0.26a, b | 5.20 ± 0.91 | 1.19 ± 0.25 | 2.93 ± 1.03 | |
| P* interaction | - | 0.430 | 0.606 | 0.109 | 0.649 | ||
BMI body mass index, MTRR methionine synthase reductase
*Adjusted for age
a P < 0.05 in comparison with AA genotype of the BMI < 24 subgroup
b P < 0.05 in comparison with AG genotype of the BMI < 24 subgroup
c P < 0.05 in comparison with GG genotype of the BMI < 24 subgroup
d P < 0.05 in comparison with AA genotype of the BMI ≥ 24 subgroup
e P = 0.084 in comparison with AG genotype of the BMI ≥ 24 subgroup
f P = 0.058 in comparison with AG genotype of the BMI ≥ 24 subgroup