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. 2016 Oct 28;6:56. doi: 10.1186/s13578-016-0121-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schematic diagram of suggested MAP4K4 downstream effectors and biological outcomes in cancer. Studies on MAP4K4 in cancer have shown that MAP4K4 regulates different biological outcomes (red boxes) trough different cell signaling pathways (boxes with different colors), implicating that MAP4K4 exerts its role in regulation of tumorigenesis and tumor progression in a biological context-dependent manner