Table 2.
Current information on MAP4K4 in cancer
| Tumor type/cell line studied | Patient prognosis correlation | Manipulation of MAP4K4 | Year of publication | Ref. | ||
|---|---|---|---|---|---|---|
| Method | Functional consequences | Suggested downstream effector | ||||
| Tumors of the digestive system | ||||||
| Colorectal cancer tissues and cell line | MAP4K4 expression was reversely correlated with overall survival and lymph node metastasis | NA | NA | NA | 2010 | [30] |
| Colorectal cancer tissues and cell line | NA | siRNA knockdown | Cell proliferation↓, colony formation↓, G0/G1 arrest and apoptosis↑ | MAPK/JNK, MDM2 | 2015 | [41] |
| Gastric cancer cells | NA | siRNA knockdown | cell proliferation↓, G1 phase arrest, apoptosis↑ and invasion↓ | Notch2, Notch3, Hes1 | 2015 | [38] |
| Hepatocellular carcinoma | MAP4K4 expression was a negative predictor of overall survival and early recurrence rate | shRNA knockdown | S phase arrest, apoptosis↑ | MAPK/JNK, NF-κB, TLRs | 2011 | [31] |
| Hepatocellular carcinoma cell line | NA | siRNA knockdown | Cell invasion↓ | MMP-2, MMP-9, NF-κB | 2010 | [40] |
| Pancreatic cancer tissues and cell lines | NA | siRNA knockdown | Cell proliferation↓, colony formation↓, invasion↓, G1 arrest, apoptosis↓, chemosensitivity↑ and xenograft tumor growth↓ | NA | 2013 | [37] |
| Stage II pancreatic ductal adenocarcinoma | MAP4K4 expression was associated with poor overall and recurrence-free survival | NA | NA | NA | 2008 | [32] |
| Head and neck cancer | ||||||
| Larynx carcinoma cell line | NA | siRNA knockdown | Cell migration↓ and invasion↓ | JNK | 2015 | [35] |
| Lung cancer | ||||||
| Lung adenocarcinoma | MAP4K4 expression was associated with shorter overall and recurrence-free survival | NA | NA | NA | 2012 | [33] |
| Lung adenocarcinoma cell lines | NA | shRNA knockdown | Cell apoptosis↑ | Survivin | 2014 | [36] |
| Gynecologic cancer | ||||||
| Ovarian carcinoma cell line | NA | siRNA knockdown | Cell motility↓ | MAPK/JNK | 2006 | [39] |
| Genitourinary cancer | ||||||
| Prostate cancer | MAP4K4 was associated with time to biochemical failure | NA | NA | NA | 2014 | [34] |
| Tumor of the central nervous system | ||||||
| Glioblastoma cell line | NA | shRNA knockdown | Cell migration↓ and invasion↓ | NA | 2013 | [26] |
| Mesenchymal tumor | ||||||
| Kaposi’s sarcoma | NA | siRNA knockdown | Reactivation of Kaposi’s sarcoma herpesvirus and cell invasion↓ | COX-2, MMP-7, MMP-13 | 2013 | [42] |
| Others | ||||||
| 60 cell lines from NCI tumor panel | NA | Kinase-inactive mutation | Anchorage-independent growth↓, cell invasion↓, cell adhesion↑ and spreading rates↑ | STAT3 | 2003 | [9] |
NA not available