Table 2.
Top 10% discriminants of adenocarcinoma
| Gene ID | Gene name | Control (mean ± SD)a | Tumor (mean ± SD)a | Fold changeb | p valuec | Ratiod | Percent (%)e | Rankf |
|---|---|---|---|---|---|---|---|---|
| SPTB | Spectrin, beta, erythrocytic | 10.7 ± 9.3 | 2.82 ± 2.6 | 0.3 | <0.0000 | (7/38) | 18 | 1 |
| SLC4A1 | Solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | 8.75 ± 5.2 | 3.8 ± 2.7 | 0.4 | <0.0000 | (9/38) | 24 | 2 |
| SPTA1 | Spectrin, alpha, erythrocytic 1 | 13.3 ± 12 | 4.28 ± 3.4 | 0.3 | <0.0000 | (8/38) | 21 | 3 |
| ANK1 | Ankyrin 1, erythrocytic | 6.28 ± 5.7 | 1.84 ± 1.8 | 0.3 | 0.0001 | (8/38) | 21 | 4 |
| EPRS | Glutamyl-prolyl-tRNA synthetase | 1.24 ± 0.87 | 3.15 ± 1.7 | 2.5 | <0.0000 | (30/38) | 79 | 5 |
| HBG1 | Hemoglobin, gamma A | 16.9 ± 9.7 | 7.44 ± 6.2 | 0.4 | <0.0000 | (9/38) | 24 | 6 |
| HBG2 | Hemoglobin, gamma G | 17 ± 9.7 | 7.43 ± 6.2 | 0.4 | <0.0000 | (9/38) | 24 | 7 |
| COPG1 | Coatomer protein complex, subunit gamma 1 | 1.56 ± 1 | 2.67 ± 1.4 | 1.7 | 0.0036 | (29/38) | 76 | 8 |
| HYOU1 | Hypoxia up-regulated 1 | 2.12 ± 1.9 | 4.74 ± 2.3 | 2.2 | <0.0000 | (31/38) | 82 | 9 |
| PTRF | Polymerase I and transcript release factor | 7.35 ± 2.8 | 3.81 ± 2.8 | 0.5 | 0.0001 | (4/38) | 11 | 10 |
| PDIA4 | Protein disulfide isomerase family A, member 4 | 2.69 ± 2.2 | 6.23 ± 3.4 | 2.3 | 0.0003 | (31/38) | 82 | 11 |
| APEX1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | 0.778 ± 0.83 | 2.05 ± 1.1 | 2.6 | <0.0000 | (32/38) | 84 | 12 |
| STOML2 | Stomatin (EPB72)-like 2 | 0.675 ± 0.39 | 1.38 ± 0.57 | 2 | 0.0084 | (32/38) | 84 | 13 |
| LRPPRC | Leucine-rich pentatricopeptide repeat containing | 1.31 ± 1.4 | 3.52 ± 2.5 | 2.7 | 0.0001 | (29/38) | 76 | 14 |
| NANS | N-acetylneuraminic acid synthase | 0.61 ± 0.55 | 1.64 ± 1.1 | 2.7 | 0.0002 | (31/38) | 82 | 15 |
| HBD | Hemoglobin, delta | 47.3 ± 32 | 21.7 ± 18 | 0.5 | 0.0001 | (8/38) | 21 | 16 |
aValues represent covariate adjusted spectral counts
bRatio of means relative to control
cFalse discovery rate adjusted mixed effects model p value
dRatio represents the number of tumor samples which indicated a higher abundance relative to matched control tissue
ePercent (%) represents number of cases were the respective protein was increased in tumor relative to control
fImportance of metabolic change based on O-PLS-DA model loading