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A schematic diagram of HOST2 enhances the endogenous expression of metastasis-promoting genes that are targeted by let-7b. A, Down-regulation of HOST2 may increase let-7b activity, which would inhibit expression of its target genes (HMGA2, c-myc, Dicer, and Imp3). B, High regulation of HOST2 binds to more let-7b and increases expression of its target genes (HMGA2, c-myc, Dicer, and Imp3).
