Table 1. Genes induced by nuclear calcium signaling (i.e., down-regulated by CaMBP4) with a role in T cell activation.
Signaling | MAPKs pathway | Transcription |
---|---|---|
PRKCQ (PKCθ) | MAP4K2 | STAT2 |
PLCG2 (PLCγ2) | RASGRP3 | SMAD3 |
Receptors | IFN signaling | SMAD4 |
CD27 | IFITM | SMAD7 |
CD8A | IRF8 | FOXO1 |
IL-2R | IFI27 | EOMES |
TGFβ R | IRFI35 | |
Cytokines | Inflammation and cytotoxic activity | Adhesion molecules |
IFNγ | KLRD1 (CD94) | ITGB2 |
IL-2 | KLRB1 | ITGAL |
IL-3 | GZMA (granzyme) | ICAM3 |
IL-4 | GZMK (granzyme) | ITGB7 |
GM-CSF (CSF2) | GZMH (granzyme) | Rho GTPase signaling |
TNFSF13B (BAFF) | PTGER2 | RAP-GEF |
TNFSF10 | ARHGAP4 |