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. 2016 Sep 24;107(10):1443–1452. doi: 10.1111/cas.13024

Figure 4.

Figure 4

Effect of calpeptin on proliferation, migration, and invasion of pancreatic stellate cells (PSCs). (a) Cell growth of PSCs was assessed with an ATP‐based assay with or without calpeptin (0, 10, 20, 40, 60, or 80 μM). Representative images of migrating (b) and invading (d) PSCs are shown. Calpeptin dose‐dependently decreased the migration (c) and invasion (e) of PSCs. Silencing of calpain‐2 decreased proliferation (f) and migration and invasion (g) of immortalized PSC (iPSC) cells. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. Cells were stained with HE; original magnification, ×100. Scale bar = 100 μm.