Table 1.
Top 10 potential tumor‐related targets of peperomin E predicted by LibDock of Discovery Studio 4.0
| Rank | PDB ID. | Libdock score | Targets |
|---|---|---|---|
| 1 | 3SWR | 155.7 | DNA (cytosine‐5)‐methyltransferase 1 (human) |
| 2 | 3AV6 | 139.5 | DNA (cytosine‐5)‐methyltransferase 1 (mouse) |
| 3 | 3TLM | 136.9 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (cattle) |
| 4 | 4EKL | 134.8 | RAC‐alpha serine/threonine‐protein kinase (human) |
| 5 | 1T5T | 132.1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (rabbit) |
| 6 | 4FJY | 130.4 | Phosphatidylinositol 4,5‐bisphosphate 3‐kinase catalytic subunit gamma isoform (human) |
| 7 | 3QKK | 130.1 | RAC‐alpha serine/threonine‐protein kinase (human) |
| 8 | 3ZK6 | 129.1 | Bcl‐2 like protein 1 (human) |
| 9 | 3ML8 | 124.0 | Phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit gamma isoform (human) |
| 10 | 3OW4 | 123.8 | RAC‐alpha serine/threonine‐protein kinase (human) |
Annotated Database of Druggable Binding Sites from the Protein DataBank (PDB) was used to identify potential binding proteins of peperomin E.