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. 2016 Sep 9;107(10):1373–1379. doi: 10.1111/cas.13027

Figure 2.

Figure 2

Structures of major oncolytic viruses. Boxes represent inverted repeat sequences flanking the long (UL) and short (US) unique sequences of HSV‐1 DNA in T‐Vec and G47∆. T‐Vec has an insertion of human GM‐CSF in both copies of the γ34.5 gene and a deletion in the α47 gene. G47∆ has a deletion in both copies of the γ34.5 gene, a deletion in the α47 gene, and an insertion of the lacZ coding sequence in the ICP6 locus. JX‐594 has an insertion of human GM‐CSF and lacZ transgenes in the TK locus. Reolysin has a segmented genome composed of ten segments of double stranded RNA and a double shell of capsid.