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. 2017 Jan;112(Pt A):76–83. doi: 10.1016/j.neuropharm.2016.08.010

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Blockade of GluN2B-containing NMDARs is sufficient to prevent induction of LTD. (A) A 20 min application of 1 μM Ro (filled diamonds) or 0.1 μM NVP (open triangles) prior to LFS is insufficient to block LTD. (B) A 30 min pre-application of 1 μM Ro (filled squares) inhibits LTD whereas a similarly long application of 0.1 μM NVP (open triangles) has no effect on LTD. (C) Summary of the experiments using 1 μM Ro showing that a 30 min pre-application time is necessary for complete blockade of LTD (filled squares, n = 5) whereas a 20 min pre-application is insufficient (filled diamonds, n = 15). (D) The data show the 4 min estimates of LTD (1 h post LFS) from single experiments. Robust inhibition of LTD is only seen with longer pre-incubation with Ro whereas a shorter application time leads to variable effects.