Table 2.
Genes repressed by Myd88-dependent signaling in 4T1 cells.
| aconsMydlow | bindMydlow | cRELEVANT ASSOCIATED FUNCTION(S) | REFS | |
|---|---|---|---|---|
| Slfn2 | 352.58 | 3.89 | Considered a negative regulator of growth. | 58 |
| Sectm1a | 6.49 | 11.34 | May function as a T cell co-stimulatory ligand. | 36 |
| Dapk2 | 6.80 | 3.53 | Can function as a pro-apoptotic protein kinase. | 33 |
| Psd4 | 4.97 | 3.44 | Can function as an antagonist for breast cancer. | 15 |
| Nlrp10 | 6.78 | 2.90 | Associated with dendritic cells and innate and adaptive immunity. | 37 |
| Rnf125 | 3.25 | 2.96 | Positive regulator of T cell activation. | 38 |
| Idi1 | 2.21 | 3.20 | Associated with breast cancer growth inhibition. | 35 |
| Creb3l3 | 5.98 | 2.12 | Growth suppressor for hepatocellular carcinoma. | 59 |
| Arl11 | 4.18 | 2.12 | May function as a tumor suppressor in lung cancer. | 32 |
| Dmp1 | 2.16 | 2.69 | May be considered a tumor suppressor in breast cancer. | 16 |
| Gng7 | 2.06 | 2.34 | Candidate tumor suppressor in Hodgkin lymphoma. | 60 |
| Usp17la | 2.06 | 2.00 | Can function as a pro-apoptotic factor and growth suppressor. | 34 |
Notes:
a
Relative upregulation of genes in consMydlow cells relative to control.
b
Relative upregulation of genes in indMydlow cells relative to control.
c
Select functions that have been attributed to the upregulated genes.